Cancer
Malignant Lip and Oral Cavity Neoplasm
CI-CAN-00001138Explore in graph →
Top-level149 active trials2 evidence items
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Cancer
CI-CAN-00001138Explore in graph →
Clinical trials
554 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (53)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT07209189 | Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)((NeoScorch HN)) | recruiting | Phase 2 | 75 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Apr 23, 2026 | clinicaltrials |
| NCT06902623 | Treatment De-Escalation for Favorable Prognosis Human Papilloma Virus (HPV) or p16-Positive Oropharyngeal Cancer Receiving Definitive Radiotherapy(Lombardi197) | recruiting | N/A | 30 | Georgetown University |
| 1 |
| Apr 17, 2026 |
| clinicaltrials |
| NCT06550050 | Clinical and Molecular Features of Oral Premalignancy and Oral Cancer | recruiting | — | 1,000 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 16, 2026 | clinicaltrials |
| NCT04870762 | Customized 3D Printed Oral Stents During Head and Neck Radiotherapy | recruiting | Phase 2 | 119 | M.D. Anderson Cancer CenterOTHER | 1 | Apr 15, 2026 | clinicaltrials |
| NCT07260344 | Evaluation of Two Non-Invasive Methods, High-Resolution Microendoscopy and Liquid-Based Cytology, for Detection of Oral Precancer | recruiting | N/A | 400 | Anil ChaturvediNIH | 1 | Apr 14, 2026 | clinicaltrials |
| NCT06097468 | Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC) | recruiting | Phase 1 / Phase 2 | 40 | University of California, San FranciscoOTHER | 1 | Apr 13, 2026 | clinicaltrials |
| NCT07509619 | AI-based Physiotherapy Evaluation System for Range of Motion in Oral Cancer Patients | recruiting | — | 20 | National Taiwan University HospitalOTHER | 1 | Apr 13, 2026 | clinicaltrials |
| NCT06785051 | AI-based Physiotherapy for Oral Cancer Patients | recruiting | N/A | 100 | National Taiwan University HospitalOTHER | 1 | Apr 3, 2026 | clinicaltrials |
| NCT06030440 | De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck(DIREKHT2) | recruiting | Phase 2 / Phase 3 | 508 | University of Erlangen-Nürnberg Medical SchoolOTHER | 1 | Mar 13, 2026 | clinicaltrials |
| NCT06868433 | TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer | recruiting | Phase 1 | 40 | Emory UniversityOTHER | 1 | Mar 4, 2026 | clinicaltrials |
| NCT06336941 | "Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON)(HOUSTON) | recruiting | N/A | 400 | University of PisaOTHER | 1 | Feb 25, 2026 | clinicaltrials |
| NCT05837221 | Microbiome in Head and Neck Squamous Cell Carcinoma | recruiting | — | 60 | University of Colorado, DenverOTHER | 1 | Feb 24, 2026 | clinicaltrials |
| NCT07063212 | A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC) | recruiting | Phase 2 | 40 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Feb 19, 2026 | clinicaltrials |
| NCT06629038 | Estimating Jaw, Neck, and Shoulder Range of Motion Using an AI Model | recruiting | — | 40 | National Taiwan University HospitalOTHER | 1 | Feb 11, 2026 | clinicaltrials |
| NCT06636734 | Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial | recruiting | Phase 2 | 28 | Emory UniversityOTHER | 1 | Feb 11, 2026 | clinicaltrials |
| NCT01473784 | Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck | recruiting | N/A | 600 | Ohio State University Comprehensive Cancer CenterOTHER | 1 | Feb 10, 2026 | clinicaltrials |
| NCT07401641 | Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial. | recruiting | N/A | 60 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | Feb 10, 2026 | clinicaltrials |
| NCT07371611 | Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma | recruiting | Phase 3 | 104 | Qunxing Li,MDOTHER | 1 | Jan 28, 2026 | clinicaltrials |
| NCT07343271 | Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx(DECT-CEco) | recruiting | — | 30 | University Hospital, Strasbourg, FranceOTHER | 1 | Jan 15, 2026 | clinicaltrials |
| NCT07296250 | Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT | recruiting | N/A | 100 | Chang Gung Memorial HospitalOTHER | 1 | Dec 22, 2025 | clinicaltrials |
| NCT07237672 | AI Based Physiotherapy 3- and 9-Month Follow-Up in Oral Cancer Patients | recruiting | N/A | 65 | National Taiwan University HospitalOTHER | 1 | Dec 16, 2025 | clinicaltrials |
| NCT05793151 | Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy(ENDURE) | recruiting | N/A | 532 | Medical University of South CarolinaOTHER | 1 | Dec 11, 2025 | clinicaltrials |
| NCT07095608 | Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain | recruiting | N/A | 80 | New York UniversityOTHER | 1 | Nov 21, 2025 | clinicaltrials |
| NCT07111455 | Prospective Cohort Study on Oral Microbiome Changes in Patients With Locally Advanced Oral Squamous Cell Carcinoma Following Neoadjuvant Chemoimmunotherapy | recruiting | — | 32 | Zhujiang HospitalOTHER | 1 | Sep 23, 2025 | clinicaltrials |
| NCT07180901 | Proactive Risk-based Optimization & Notifications for Treatment & Outcomes in Head & Neck Cancer(PRONTO-HN) | recruiting | N/A | 85 | Centre hospitalier de l'Université de Montréal (CHUM)OTHER | 1 | Sep 18, 2025 | clinicaltrials |
| NCT05757817 | Evaluation of the Benefit of a New Surgical Procedure According to IDEAL Recommendations for ORL Cancer Patients: the External Pudendal Flap Used as a New Free Flap for Oral Cavity/Oropharyngeal Reconstruction to Limit Donor Site Sequelae(LAMBEAU STEPA) | recruiting | N/A | 40 | Institut Claudius RegaudOTHER | 1 | Sep 15, 2025 | clinicaltrials |
| NCT07133958 | A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC | recruiting | — | 35 | Zhujiang HospitalOTHER | 1 | Aug 21, 2025 | clinicaltrials |
| NCT05774483 | Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative(SECOND N0) | recruiting | N/A | 508 | Tata Memorial HospitalOTHER_GOV | 1 | Jul 17, 2025 | clinicaltrials |
| NCT05740033 | Radial Forearm Donor Site Closure | recruiting | N/A | 120 | University of British ColumbiaOTHER | 1 | Jun 12, 2025 | clinicaltrials |
| NCT06321003 | SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography(SYMILIS OCT) | recruiting | — | 200 | University of PalermoOTHER | 1 | May 23, 2025 | clinicaltrials |
| NCT05144698 | RAPA-201 Therapy of Solid Tumors | recruiting | Phase 1 / Phase 2 | 37 | Rapa Therapeutics LLCINDUSTRY | 1 | May 14, 2025 | clinicaltrials |
| NCT04809324 | Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers | recruiting | N/A | 1,206 | Dr.Pankaj ChaturvediOTHER | 1 | Apr 11, 2025 | clinicaltrials |
| NCT05337631 | Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy(SENIOR) | recruiting | — | 1,500 | University Hospital FreiburgOTHER | 5 | Mar 25, 2025 | clinicaltrials |
| NCT06737822 | Upfront Surgery Vs Induction Chemotherapy Followed By Surgery In Oral Cancers:(SurVIC) | recruiting | Phase 3 | 346 | All India Institute of Medical Sciences, JodhpurOTHER_GOV | 1 | Mar 4, 2025 | clinicaltrials |
| NCT05451303 | Detection of Oral and Throat Cancers Using OralViome Cancer Testing System | recruiting | — | 475 | ViomeINDUSTRY | 1 | Jan 29, 2025 | clinicaltrials |
| NCT06174428 | Validity of Viome's Oral/throat Cancer Test | recruiting | — | 1,000 | ViomeINDUSTRY | 1 | Jan 29, 2025 | clinicaltrials |
| NCT06380686 | Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome(HEAT) | recruiting | — | 120 | AIO-Studien-gGmbHOTHER | 1 | Nov 13, 2024 | clinicaltrials |
| NCT06662929 | Arabic PRO Measures for Head and Neck Cancer Radiotherapy.(PROMs) | recruiting | — | 125 | King Saud UniversityOTHER | 1 | Oct 29, 2024 | clinicaltrials |
| NCT05382585 | Newer Therapeutic Targets in Head and Neck Cancers | recruiting | — | 200 | Banaras Hindu UniversityOTHER | 1 | Aug 13, 2024 | clinicaltrials |
| NCT05798793 | Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcinoma(NEOPCOSCC) | recruiting | Phase 3 | 309 | Hospital of Stomatology, Wuhan UniversityOTHER | 1 | Apr 2, 2024 | clinicaltrials |
| NCT05098119 | Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002) | recruiting | Phase 2 | 43 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | Mar 26, 2024 | clinicaltrials |
| NCT05069857 | Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients | recruiting | Phase 2 | 46 | Shanghai Jiao Tong University School of MedicineOTHER | 1 | Nov 22, 2023 | clinicaltrials |
| NCT05125055 | Neoadjuvant Anti-PD-1 and TP Versus TPF on Pathological Response in OSCC | recruiting | Phase 2 / Phase 3 | 80 | Shanghai Jiao Tong University School of MedicineOTHER | 1 | Nov 22, 2023 | clinicaltrials |
| NCT06130332 | Neoadjuvant Tirellizumab Combined With Chemotherapy for Early Oral Squamous Cell Carcinoma(HNC-SYSU-004) | recruiting | Phase 2 | 40 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | Nov 14, 2023 | clinicaltrials |
| NCT05980702 | 4 Courses vs 2 Courses of Pembrolizumab Combined With Carboplatin and Albumin-binding Paclitaxel of Neoadjuvant Therapy in HNSCC(HNC-SYSU-002) | recruiting | Phase 2 | 192 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | Sep 7, 2023 | clinicaltrials |
| NCT05862168 | Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma ：A Single-arm, Prospective, Phase II Trial | recruiting | Phase 2 | 30 | Weijia Fang, MDOTHER | 1 | Jul 17, 2023 | clinicaltrials |
| NCT05941338 | Tirelizumab in Combination With Carboplatin and Albumin-binding Paclitaxel for Neoadjuvant Therapy in HNSCC(HNC-SYSU-001) | recruiting | Phase 2 | 100 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityOTHER | 1 | Jul 12, 2023 | clinicaltrials |
| NCT05872880 | TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. | recruiting | — | 124 | Xiangya Hospital of Central South UniversityOTHER | 1 | May 24, 2023 | clinicaltrials |
| NCT05375266 | Immune Biomarker Study for Head and Neck Cancer(ImmunBio-KHT) | recruiting | — | 1,100 | University of Erlangen-Nürnberg Medical SchoolOTHER | 1 | May 17, 2023 | clinicaltrials |
| NCT03385720 | Submandibular Gland Preservation in Neck Dissection | recruiting | N/A | 200 | Guang-Yan YuOTHER | 1 | Mar 30, 2023 | clinicaltrials |
Data updated 22 days agoSource updated Apr 23, 2026source: clinicaltrials