Low Grade Glioma — Variants & evidence

Low Grade Glioma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

105 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 101–105 of 105 evidence items (5 on this page mapped to a descendant entity) · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RELA Fusion5
(prognostic)	Supratentorial Ependymoma ZFTA Fusion-Positive	Prognostic	B	Supports Poor Outcome	3	rejected	EID11439 Pajtler et al. generated genome-wide DNA methylation profiles for 500 ependymal tumors using the Illumina 450k methylation array. Tumors were classified into nine molecular subgroups of which 88 supra… (full text at CIViC) PMID 25965575 · Pajtler et al., 2015 · Open in CIViC	civic
(diagnostic)	Supratentorial Ependymoma ZFTA Fusion-Positive	Diagnostic	B	Supports Positive	3	accepted	EID11440 Pajtler et al. generated genome-wide DNA methylation profiles for 500 ependymal tumors using the Illumina 450k methylation array. Tumors were classified into nine molecular subgroups of which 88 supra… (full text at CIViC) PMID 25965575 · Pajtler et al., 2015 · Open in CIViC	civic
〃	Supratentorial Ependymoma ZFTA Fusion-Positive	Diagnostic	B	Supports Positive	3	accepted	EID11448 Paired-end RNA sequencing identified a fusion between C11orf95 (now known as ZFTA) and RELA in 14 of 19 supratentorial ependymomas. This fusion was not detectable in a series of other CNS tumors incl… (full text at CIViC) PMID 24562983 · Pietsch et al., 2014 · Open in CIViC	civic
(oncogenic)	Supratentorial Ependymoma ZFTA Fusion-Positive	Oncogenic	D	Supports Oncogenicity	4	accepted	EID11441 Fusions between ZFTA (C11orf95) and RELA are identified in 70% of supratentorial ependymomas. RELA is the principal effector of NF-KB signaling. The introduction of the fusion into neural stem cell… (full text at CIViC) PMID 24553141 · Parker et al., 2014 · Open in CIViC	civic
〃	Supratentorial Ependymoma ZFTA Fusion-Positive	Oncogenic	D	Supports Oncogenicity	4	accepted	EID11442 Viral introduction of the ZFTA::RELA fusion into periventricular neural stem cells in mice was shown to induce tumors that recapitulate human supratentorial ependymoma. Introduction of wild type ZFT… (full text at CIViC) PMID 29949764 · Ozawa et al., 2018 · Open in CIViC	civic

Data updated 17 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.