Cancer Family
Head and Neck Neoplasm
CI-CAN-00000021Explore in graph →
Non-malignant1,571 active trials17 approved drugs142 evidence items
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Cancer Family
CI-CAN-00000021Explore in graph →
Clinical trials
6,372 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT06790966 | Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma(VERSATILE-003) | terminated | Phase 3 | 12 | PDS Biotechnology Corp.INDUSTRY | 1 | Sep 2, 2026 | clinicaltrials |
| NCT03637335 | Comparing Palliative Radiotherapy With or Without Carboplatin(METAXIOM) | terminated | Phase 3 | 26 | Institut Cancerologie de l'OuestOTHER | 1 | Jun 9, 2026 |
| clinicaltrials |
| NCT04222972 | A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)(AcceleRET-Lung) | terminated | Phase 3 | 223 | Hoffmann-La RocheINDUSTRY | 22 | Mar 5, 2026 | clinicaltrials |
| NCT05386550 | Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION) | terminated | Phase 3 | 166 | EMD Serono Research & Development Institute, Inc.INDUSTRY | 26 | Feb 19, 2026 | clinicaltrials |
| NCT04459715 | A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX) | terminated | Phase 3 | 730 | EMD Serono Research & Development Institute, Inc.INDUSTRY | 26 | Oct 8, 2025 | clinicaltrials |
| NCT04458909 | Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer | terminated | Phase 3 | 15 | National Cancer Institute (NCI)NIH | 4 | Oct 3, 2025 | clinicaltrials |
| NCT02363400 | A Phase III Trial in NPC With Post-radiation Detectable Plasma EBV DNA | terminated | Phase 3 | 10 | National Health Research Institutes, TaiwanOTHER | 1 | Aug 19, 2025 | clinicaltrials |
| NCT05930938 | Study Comparing RT With Cetuximab + Xevinapant to RT With Cetuximab-placebo in Patients With Head and Neck Cancer(XXL_2022-01) | terminated | Phase 3 | 19 | Groupe Oncologie Radiotherapie Tete et CouOTHER | 1 | May 9, 2025 | clinicaltrials |
| NCT00448240 | Erlotinib (Tarceva) During First Line Standard Platinum Containing Chemo for Advanced Squamous Cell Head and Neck Cancer | terminated | Phase 2 / Phase 3 | 6 | Henry Ford Health SystemOTHER | 0 | Mar 18, 2025 | clinicaltrials |
| NCT03452137 | A Study of Atezolizumab (Anti-PD-L1 Antibody) as Adjuvant Therapy After Definitive Local Therapy in Patients With High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck(IMvoke010) | terminated | Phase 3 | 406 | Hoffmann-La RocheINDUSTRY | 23 | Oct 9, 2024 | clinicaltrials |
| NCT04428333 | Study of GSK3359609 With Pembrolizumab and 5-fluorouracil (5-FU)-Platinum Chemotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma(INDUCE-4) | terminated | Phase 3 | 117 | GlaxoSmithKlineINDUSTRY | 19 | Oct 9, 2024 | clinicaltrials |
| NCT04128696 | Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 (PD-L1) Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma(INDUCE-3) | terminated | Phase 3 | 315 | GlaxoSmithKlineINDUSTRY | 26 | Jul 10, 2024 | clinicaltrials |
| NCT04969861 | BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36) | terminated | Phase 2 / Phase 3 | 1 | Nektar TherapeuticsINDUSTRY | 4 | Jan 12, 2023 | clinicaltrials |
| NCT02419664 | Ga-68-DOTATOC -PET in the Management of Pituitary Tumours | terminated | Phase 3 | 22 | Göteborg UniversityOTHER | 1 | Mar 31, 2022 | clinicaltrials |
| NCT00198315 | Medpulser Electroporation With Bleomycin Study to Treat Anterior Head and Neck Squamous Cell Carcinoma | terminated | Phase 3 | 130 | Inovio PharmaceuticalsINDUSTRY | 1 | Mar 4, 2022 | clinicaltrials |
| NCT03682367 | Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery | terminated | Phase 3 | 8 | University of California, DavisOTHER | 1 | Jul 9, 2021 | clinicaltrials |
| NCT01126216 | Reduced Radiotherapy With Pac/Cis vs Standard Radiotherapy With 5-FU/Cis in Locally Advanced Head and Neck Cancer(Paccis-RCT) | terminated | Phase 3 | 221 | University of Erlangen-Nürnberg Medical SchoolOTHER | 1 | May 4, 2021 | clinicaltrials |
| NCT01687413 | Post Operative Adjuvant Therapy De-intensification Trial for Human Papillomavirus-related, p16+ Oropharynx Cancer(ADEPT) | terminated | Phase 3 | 42 | Washington University School of MedicineOTHER | 1 | Nov 25, 2020 | clinicaltrials |
| NCT02236936 | Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck(AGMT_HNO_PN) | terminated | Phase 3 | 8 | Arbeitsgemeinschaft medikamentoese TumortherapieOTHER | 1 | May 1, 2020 | clinicaltrials |
| NCT02137096 | Autologous Stem Cell Transplantation for Patients With Recurrent Nasopharyngeal Carcinoma | terminated | Phase 3 | 1 | University of FloridaOTHER | 1 | Jun 24, 2019 | clinicaltrials |
| NCT02131155 | LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy | terminated | Phase 3 | 36 | Boehringer IngelheimINDUSTRY | 4 | Mar 1, 2019 | clinicaltrials |
| NCT00828386 | Induction Chemotherapy and Chemoradiotherapy in Nasopharyngeal Cancers(NPC2006) | terminated | Phase 3 | 83 | Groupe Oncologie Radiotherapie Tete et CouOTHER | 4 | Jan 18, 2019 | clinicaltrials |
| NCT00360971 | Palifermin in Lessening Oral Mucositis in Patients Undergoing Radiation Therapy and Chemotherapy for Locally Advanced Head and Neck Cancer | terminated | Phase 3 | 21 | Radiation Therapy Oncology GroupNETWORK | 2 | Dec 26, 2017 | clinicaltrials |
| NCT01345669 | LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy | terminated | Phase 3 | 617 | Boehringer IngelheimINDUSTRY | 29 | Dec 7, 2017 | clinicaltrials |
| NCT00412217 | A Study of Erlotinib (Tarceva) in Participants With Resected Head and Neck Squamous Cell Cancer | terminated | Phase 3 | 94 | Hoffmann-La RocheINDUSTRY | 1 | Nov 25, 2016 | clinicaltrials |
| NCT01507467 | IAEA-HypoX. Accelerated Radiotherapy With or Without Nimorazole in Squamous Cell Carcinoma of the Head and Neck(IAEA-HypoX) | terminated | Phase 3 | 104 | Danish Head and Neck Cancer GroupNETWORK | 4 | Nov 25, 2016 | clinicaltrials |
| NCT00537199 | OraTest in Combination With Visual Examination and Visual Examination Alone | terminated | Phase 3 | 1 | M.D. Anderson Cancer CenterOTHER | 1 | May 13, 2016 | clinicaltrials |
| NCT01161498 | Study of Safety and Efficacy of Talimogene Laherparepvec With Cisplatin and Radiotherapy for Treatment of Locally Advanced Head and Neck Cancer | terminated | Phase 3 | 5 | BioVex LimitedINDUSTRY | 2 | Feb 8, 2016 | clinicaltrials |
| NCT00412776 | Study of Proxinium Plus Best Supportive Care Versus Best Supportive Care for Patients With Advanced Head and Neck Cancer | terminated | Phase 2 / Phase 3 | 165 | Sesen Bio, Inc.INDUSTRY | 18 | Dec 23, 2015 | clinicaltrials |
| NCT00006994 | S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat | terminated | Phase 3 | 23 | SWOG Cancer Research NetworkNETWORK | 2 | Nov 18, 2015 | clinicaltrials |
| NCT00088907 | Phase III Trial Of Docetaxel Versus Docetaxel Plus ZD1839 In Head And Neck Cancer | terminated | Phase 3 | 270 | National Cancer Institute (NCI)NIH | 1 | May 6, 2015 | clinicaltrials |
| NCT00934739 | A Study of High-Risk Oral Cavity Cancer | terminated | Phase 2 / Phase 3 | 150 | National Health Research Institutes, TaiwanOTHER | 0 | Feb 25, 2015 | clinicaltrials |
| NCT00911326 | Evaluation of Sentinel Lymph Nodes in Head and Neck Squamous Cell Carcinoma | terminated | Phase 3 | 101 | Navidea BiopharmaceuticalsINDUSTRY | 1 | Aug 8, 2014 | clinicaltrials |
| NCT02183246 | Porfiromycin Used as an Adjuvant to Radiation Therapy in Postoperative Head and Neck Cancer Patients | terminated | Phase 3 | 3 | Boehringer IngelheimINDUSTRY | 0 | Jul 8, 2014 | clinicaltrials |
| NCT00507429 | Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid Cancer(FACT) | terminated | Phase 2 / Phase 3 | 80 | Mateon TherapeuticsINDUSTRY | 12 | Jun 9, 2014 | clinicaltrials |
| NCT00004227 | Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III or Stage IV Cancer of the Oropharynx, Hypopharynx, or Larynx | terminated | Phase 3 | 32 | University of Alabama at BirminghamOTHER | 1 | Feb 6, 2014 | clinicaltrials |
| NCT00574860 | EN3285 for the Prevention or Delay of Oral Mucositis in Patients With Head and Neck Cancer | terminated | Phase 3 | 240 | Endo USA Inc., a Keenova Therapeutics CompanyINDUSTRY | 1 | Sep 20, 2013 | clinicaltrials |
| NCT00113399 | Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery | terminated | Phase 3 | 15 | Radiation Therapy Oncology GroupNETWORK | 1 | Jul 2, 2013 | clinicaltrials |
| NCT00128817 | Concurrent Chemoradiation Versus Surgery With Adjuvant Therapy in Advanced Laryngopharyngeal Cancers | terminated | Phase 3 | 900 | Tata Memorial HospitalOTHER_GOV | 1 | Jan 23, 2013 | clinicaltrials |
| NCT01066741 | Prevention of Radiation-induced Severe Oral Mucositis in Oral Cavity, Oropharynx, Hypopharynx, and Cavum Cancer | terminated | Phase 3 | 78 | Centre Leon BerardOTHER | 1 | Nov 1, 2012 | clinicaltrials |
| NCT00268372 | S0427, Combination Chemotherapy & RT in Treating Patients With Stage III or Stage IV Cancer of the Oropharynx | terminated | Phase 3 | 6 | SWOG Cancer Research NetworkNETWORK | 1 | Oct 4, 2012 | clinicaltrials |
| NCT00017277 | Radiation Therapy With or Without Epoetin Alfa in Treating Patients With Head and Neck Cancer | terminated | Phase 3 | 47 | European Organisation for Research and Treatment of Cancer - EORTCNETWORK | 10 | Sep 24, 2012 | clinicaltrials |
| NCT00201344 | A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage Nasopharyngeal Carcinoma Patients | terminated | Phase 3 | 320 | National Health Research Institutes, TaiwanOTHER | 1 | Mar 26, 2010 | clinicaltrials |
Data updated 22 days agoSource updated Sep 2, 2026source: clinicaltrials