Clear Cell Renal Cell Carcinoma — Variants & evidence

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Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
VHL P86fs (c.255_256delGC)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6136 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL P86H (c.257C>A)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6137 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL Q145H (c.435G>T)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6155 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL Q164* (c.490C>T)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID6925 Tumors from 98 patients with sporadic clear cell renal cell carcinoma (ccRCC) were analyzed for VHL mutations and loss of heterozygosity (LOH). Somatic VHL variants were observed in 56 patients, and V… (full text at CIViC) PMID 7915601 · Gnarra et al., 1994 · Open in CIViC	civic
VHL Q96* (c.286C>T)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6143 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL R60fs (c.178_179del)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6128 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL S139fs (c.415insC)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6150 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL S65L (c.194C>T)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID6131 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL S65P (c.193T>C)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6130 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL S68* (c.203C>A)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6132 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL T124fs (c.370_371insTGCAGGA)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6148 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL T157fs (c.469delA)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	2	submitted	EID6158 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL V155M (c.463G>A)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6157 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL V166fs (c.498delC)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6162 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL W88* (c.263G>A)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6138 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL Y175* (c.525C>A)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID6166 This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC) PMID 11505222 · Gallou et al., 2001 · Open in CIViC	civic
VHL Y98FS (c.291_310del20)1
(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID1951 This variant was detected in a single case with clear-cell renal cell carcinoma. The tumor had two somatic variants (c.1-1_20del21 and c.291_310del20). Either of these variants is predicted to be quit… (full text at CIViC) PMID 15932632 · van Houwelingen et al., 2005 · Open in CIViC	civic

Therapy

Type

Level

Direction · significance

Rating (1–5)

Status

Evidence

Source

VHL P86fs (c.255_256delGC)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6136

This study analyzed tumor and non-tumor kidney tissue from 195 unrelated patients with sporadic clear cell renal cell carcinoma (CCRCC) for a relationship between VHL variants in sporadic CCRCC and 'g… (full text at CIViC)

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL P86H (c.257C>A)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6137

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL Q145H (c.435G>T)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6155

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL Q164* (c.490C>T)1

(oncogenic)

Oncogenic

Supports Oncogenicity

accepted

EID6925

Tumors from 98 patients with sporadic clear cell renal cell carcinoma (ccRCC) were analyzed for VHL mutations and loss of heterozygosity (LOH). Somatic VHL variants were observed in 56 patients, and V… (full text at CIViC)

PMID 7915601 · Gnarra et al., 1994 · Open in CIViC

civic

VHL Q96* (c.286C>T)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6143

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL R60fs (c.178_179del)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6128

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL S139fs (c.415insC)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6150

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL S65L (c.194C>T)1

(oncogenic)

Oncogenic

Supports Oncogenicity

accepted

EID6131

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL S65P (c.193T>C)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6130

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL S68* (c.203C>A)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6132

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL T124fs (c.370_371insTGCAGGA)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6148

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL T157fs (c.469delA)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6158

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL V155M (c.463G>A)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6157

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL V166fs (c.498delC)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6162

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL W88* (c.263G>A)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6138

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL Y175* (c.525C>A)1

(oncogenic)

Oncogenic

Supports Oncogenicity

submitted

EID6166

PMID 11505222 · Gallou et al., 2001 · Open in CIViC

civic

VHL Y98FS (c.291_310del20)1

(oncogenic)

Oncogenic

Supports Oncogenicity

accepted

EID1951

This variant was detected in a single case with clear-cell renal cell carcinoma. The tumor had two somatic variants (c.1-1_20del21 and c.291_310del20). Either of these variants is predicted to be quit… (full text at CIViC)

PMID 15932632 · van Houwelingen et al., 2005 · Open in CIViC

civic

Curated clinical evidence by variant and therapy