Cancer Family
Central Nervous System Neoplasm
CI-CAN-00000118Explore in graph →
Non-malignant1,345 active trials7 approved drugs177 evidence items
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Cancer Family
CI-CAN-00000118Explore in graph →
Clinical trials
5,058 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04514393 | Ibrutinib With Methotrexate and Temozolomide for Patients With Newly Diagnosed Primary CNS Lymphoma | unknown | Phase 2 | 33 | Huiqiang HuangOTHER | 1 | Apr 7, 2022 | clinicaltrials |
| NCT05177185 | Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife(HiSparCK) | unknown | Phase 2 | 70 | Ottawa Hospital Research InstituteOTHER | 0 | Feb 16, 2022 | clinicaltrials |
| NCT05207904 | Tislelizumab Plus Chemotherapy as First-Line Treatment for Advanced Squamous NSCLC With Brain Metastases | unknown | Phase 2 | 41 | Sun Yat-sen UniversityOTHER | 1 | Jan 26, 2022 | clinicaltrials |
| NCT03400917 | Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Newly Diagnosed Glioblastoma | unknown | Phase 2 | 55 | Aivita Biomedical, Inc.INDUSTRY | 1 | Dec 16, 2021 | clinicaltrials |
| NCT04888611 | Neoadjuvant PD-1 Antibody Alone or Combined With DC Vaccines for Recurrent Glioblastoma | unknown | Phase 2 | 40 | Huashan HospitalOTHER | 1 | Nov 30, 2021 | clinicaltrials |
| NCT05131711 | Combination of Stereotactic Radiosurgery and Enhanced Immunotherapy for Recurrent Glioblastomas(inSituVac2)(CSREIG)(CSREIG) | unknown | Phase 1 / Phase 2 | 60 | Beijing Tiantan HospitalOTHER | 1 | Nov 23, 2021 | clinicaltrials |
| NCT05125666 | Efficacy of Dual Task Training on Children With Ataxia After Medulloblastoma Resection | unknown | Phase 2 | 30 | Cairo UniversityOTHER | 1 | Nov 18, 2021 | clinicaltrials |
| NCT00983398 | Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors | unknown | Phase 1 / Phase 2 | 17 | OHSU Knight Cancer InstituteOTHER | 1 | Oct 26, 2021 | clinicaltrials |
| NCT00293475 | Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma | unknown | Phase 1 / Phase 2 | 81 | OHSU Knight Cancer InstituteOTHER | 1 | Sep 22, 2021 | clinicaltrials |
| NCT03932981 | First-line Chemotherapy With Temozolomide Alone for Non-enhancing Adult Brainstem Gliomas, With a Diffuse Subtype and Showing Clinical and/or Radiological Infiltrative Pattern of Progression(TEMOTRAD01) | unknown | Phase 2 | 60 | Assistance Publique - Hôpitaux de ParisOTHER | 1 | Sep 10, 2021 | clinicaltrials |
| NCT05033587 | Study of AK105 With Anlotinib and Radiotherapy Adjuvant Therapy in MGMT Unmethylated Newly Diagnosed Glioblastoma. | unknown | Phase 2 | 28 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolOTHER | 1 | Sep 5, 2021 | clinicaltrials |
| NCT05021770 | Orelabrutinib in Combination With Thiotepa in Refractory and Relapsed Primary CNS Lymphoma | unknown | Phase 1 / Phase 2 | 29 | Huiqiang HuangOTHER | 1 | Aug 26, 2021 | clinicaltrials |
| NCT04990271 | A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma | unknown | Phase 2 | 92 | Chengdu Kanghong Biotech Co., Ltd.INDUSTRY | 1 | Aug 4, 2021 | clinicaltrials |
| NCT04129710 | A Trial to Compare Ibrutinib Versus Lenalidomide in Combination With MRE-chemotherapy for Adult Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL) | unknown | Phase 2 | 120 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Jul 16, 2021 | clinicaltrials |
| NCT04938297 | Rituximab,Zanubrutinib in Combination With Lenalidomide, Followed by Zanubrutinib or Lenalidomide Maintenance in Patients With Primary or Secondary CNS Lymphoma | unknown | Phase 2 | 100 | Henan Cancer HospitalOTHER_GOV | 1 | Jun 24, 2021 | clinicaltrials |
| NCT04760431 | TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN) | unknown | Phase 2 | 120 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Jun 2, 2021 | clinicaltrials |
| NCT04899427 | Phase II Study of Orelabrutinib Combined With PD-1 Inhibitor in Relapsed/Refractory Primary Central Nervous System Lymphoma | unknown | Phase 2 | 32 | Peking Union Medical College HospitalOTHER | 1 | May 24, 2021 | clinicaltrials |
| NCT04899453 | Intravitreal MTX and ZR Regimen in Newly Diagnosed PVRL | unknown | Phase 2 | 42 | Peking Union Medical College HospitalOTHER | 1 | May 24, 2021 | clinicaltrials |
| NCT03008148 | Phase II/III Trial of CCRT With or Without JP001 for Newly Diagnosed GBM | unknown | Phase 2 / Phase 3 | 288 | Johnpro Biotech, Inc.INDUSTRY | 1 | May 11, 2021 | clinicaltrials |
| NCT04874506 | MBM-02 (Tempol) for the Treatment of Glioblastoma Multiforme (GBM) | unknown | Phase 2 | 55 | Matrix Biomed, Inc.INDUSTRY | 1 | May 5, 2021 | clinicaltrials |
| NCT03025893 | A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme(STELLAR) | unknown | Phase 2 / Phase 3 | 100 | Amsterdam UMC, location VUmcOTHER | 1 | Apr 19, 2021 | clinicaltrials |
| NCT04822805 | A Study of Anlotinib in the Treatment of Recurrent High-grade Glioma | unknown | Phase 2 | 27 | First People's Hospital of HangzhouOTHER | 1 | Mar 30, 2021 | clinicaltrials |
| NCT04801342 | Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases | unknown | Phase 2 | 72 | National Taiwan University HospitalOTHER | 1 | Mar 17, 2021 | clinicaltrials |
| NCT04772846 | Chloroquine for Glioblastoma. | unknown | Phase 1 / Phase 2 | 60 | Egyptian Medical SyndicateOTHER | 1 | Feb 26, 2021 | clinicaltrials |
| NCT03941626 | Autologous CAR-T/TCR-T Cell Immunotherapy for Solid Malignancies | unknown | Phase 1 / Phase 2 | 50 | Shenzhen BinDeBio Ltd.INDUSTRY | 1 | Feb 4, 2021 | clinicaltrials |
| NCT04725214 | Anlotinib Combined With STUPP for MGMT Nonmethylated Glioblastoma | unknown | Phase 2 | 33 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Jan 26, 2021 | clinicaltrials |
| NCT04715620 | Niraparib Combined With Radiotherapy in rGBM | unknown | Phase 2 | 30 | Tianjin Huanhu HospitalOTHER | 1 | Jan 20, 2021 | clinicaltrials |
| NCT04675008 | Central Nervous System(CNS) Efficacy of Dacomitinib | unknown | Phase 2 | 30 | Samsung Medical CenterOTHER | 1 | Jan 5, 2021 | clinicaltrials |
| NCT04674527 | Pilot Study of Elemene in Treating Patients With Refractory Glioblastoma | unknown | Phase 2 | 30 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Dec 19, 2020 | clinicaltrials |
| NCT04668508 | Anlotinib to Malignant Brainstem Glioma | unknown | Phase 2 | 25 | Zhejiang Cancer HospitalOTHER | 1 | Dec 16, 2020 | clinicaltrials |
| NCT04583020 | Neoadjuvant PD-1 in Newly Diagnosed Glioblastoma | unknown | Phase 2 | 42 | Peking Union Medical College HospitalOTHER | 1 | Nov 30, 2020 | clinicaltrials |
| NCT03569995 | [CREMA]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma | unknown | Phase 2 | 35 | Won Seog KimOTHER | 1 | Oct 22, 2020 | clinicaltrials |
| NCT04457869 | A Study of F520 in Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) or Secondary Central Nervous System Lymphoma (SCNSL) | unknown | Phase 2 | 43 | Shandong New Time Pharmaceutical Co., LTDINDUSTRY | 0 | Oct 22, 2020 | clinicaltrials |
| NCT04588987 | Neoadjuvant Carilizumab and Apatinib for Recurrent High-Grade Glioma | unknown | Phase 2 | 60 | Sun Yat-sen UniversityOTHER | 1 | Oct 19, 2020 | clinicaltrials |
| NCT04552977 | A Trail of Fluzoparil in Combination With Temozolomide in Patients With Recurrent Glioblastoma | unknown | Phase 2 | 50 | Shandong Cancer Hospital and InstituteOTHER | 0 | Sep 17, 2020 | clinicaltrials |
| NCT04547621 | HSRT and IMRT Chemoradiotherapy for Newly Diagnosed GBM(HSCK-010) | unknown | Phase 1 / Phase 2 | 50 | Huashan HospitalOTHER | 1 | Sep 14, 2020 | clinicaltrials |
| NCT04547855 | Anlotinib Combined With Dose-dense Temozolomide for the First Recurrent or Progressive Glioblastoma After STUPP Regimen | unknown | Phase 2 | 54 | Yonggao MouOTHER | 1 | Sep 14, 2020 | clinicaltrials |
| NCT01567202 | Study of DC Vaccination Against Glioblastoma | unknown | Phase 2 | 100 | Huashan HospitalOTHER | 1 | Sep 9, 2020 | clinicaltrials |
| NCT04516655 | A Phase II Trail of Chidamide ,Rituximab and Methotrexate in Lymphoma Patients(C-R-HDMTX) | unknown | Phase 2 | 51 | Fudan UniversityOTHER | 0 | Aug 18, 2020 | clinicaltrials |
| NCT04450160 | Trial of AEO in New Glioblastoma (GBM)(AEO) | unknown | Phase 2 | 80 | MetVital, Inc.INDUSTRY | 0 | Jun 29, 2020 | clinicaltrials |
| NCT04425681 | Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer(OWBLM) | unknown | Phase 2 | 20 | Second Affiliated Hospital of Nanchang UniversityOTHER | 1 | Jun 11, 2020 | clinicaltrials |
| NCT04388033 | Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-naïve GBM Patients. | unknown | Phase 1 / Phase 2 | 10 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Jun 9, 2020 | clinicaltrials |
| NCT04120350 | R2-MTX With Lenalidomide Maintenance in Newly-diagnosed PCNSL:a Multicenter Phase Ib/II Stuty(REMLA) | unknown | Phase 1 / Phase 2 | 47 | Peking Union Medical College HospitalOTHER | 1 | Jun 5, 2020 | clinicaltrials |
| NCT04158947 | A Study of HER2+ Breast Cancer Patients With Active Brain Metastases Treated With Afatinib & T-DM1 vs. T-DM1 Alone(HER2BAT) | unknown | Phase 2 | 130 | xuexin heOTHER | 1 | May 12, 2020 | clinicaltrials |
| NCT04335357 | TBR-760 in Adult Patients With Non-Functioning Pituitary Adenomas | unknown | Phase 2 | 150 | Tiburio TherapeuticsINDUSTRY | 0 | Apr 6, 2020 | clinicaltrials |
| NCT00798811 | High-dose Chemotherapy With Autologous Stem Cell Rescue in Pediatric High-risk Brain Tumors | unknown | Phase 2 | 100 | Samsung Medical CenterOTHER | 1 | Mar 19, 2020 | clinicaltrials |
| NCT02715297 | Adjuvant Stereotactic Fractionated Radiotherapy to the Resection Cavity in Recurrent Glioblastoma(GlioCave/NOA17) | unknown | Phase 2 | 162 | Technical University of MunichOTHER | 1 | Mar 10, 2020 | clinicaltrials |
| NCT04244708 | The Effect of Chemoradiotherapy in Patients With Refractory Pituitary Adenomas | unknown | Phase 2 / Phase 3 | 150 | Peking Union Medical College HospitalOTHER | 0 | Jan 28, 2020 | clinicaltrials |
| NCT04224441 | Repurposing Chlorpromazine in the Treatment of Glioblastoma(RACTAC) | unknown | Phase 2 | 41 | Marco G Paggi, MD, PhDOTHER | 1 | Jan 13, 2020 | clinicaltrials |
Data updated 22 days agoSource updated Apr 7, 2022source: clinicaltrials